I own a classic Creamback 75W that I absolutely love, spanky bass, aggressive, yet defined mids, creamy-yet-clear highs, but I found it can sometimes soften high-gain rhythm guitar riffs, so after research I decided to go for the NEO and man, NEO is indeed the one (sorry, I had to).
It's still got the characteristics of a classic Creamback, but with extra projection around 2kHz (which is perfect for recording any genre and cutting through), it's even faster/spankier and it's got an extended (yet not irritating Vintage30-style) top end, that captures the pick and string noise if needed!
I use both my Cream 75W and Neo Cream in a handmade 2x12 ADA-spec cab in the studio and with those two I can record anything.
I don't think I'll be researching speakers for many many years!